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The Enhancement Effect of Gold Nanoparticles in Drug Delivery and as Biomarkers of Drug‐Resistant Cancer Cells
Author(s) -
Li Jingyuan,
Wang Xuemei,
Wang Chunxia,
Chen Baoan,
Dai Yongyuan,
Zhang Renyun,
Song Min,
Lv Gang,
Fu Degang
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600264
Subject(s) - cancer cell , confocal microscopy , drug , k562 cells , fluorescence microscope , drug delivery , chemistry , colloidal gold , multiple drug resistance , drug resistance , nanotechnology , cytotoxicity , biophysics , fluorescence , cancer , cell , nanoparticle , pharmacology , in vitro , materials science , biochemistry , medicine , microbiology and biotechnology , biology , quantum mechanics , antibiotics , physics
The enhancement effect of 3‐mercaptopropionic acid capped gold nanoparticles (NPs) in drug delivery and as biomarkers of drug‐resistant cancer cells has been demonstrated through fluorescence microscopy and electrochemical studies. The results of cell viability experiments and confocal fluorescence microscopy studies illustrate that these functionalized Au NPs could play an important role in efficient drug delivery and biomarking of drug‐resistant leukemia K562/ADM cells. This could be explored as a novel strategy to inhibit multidrug resistance in targeted tumor cells and as a sensitive method for the early diagnosis of certain cancers. Our observations also indicate that the interaction between the functionalized Au NPs and biologically active molecules on the surface of leukemia cells may contribute the observed enhancement in cellular drug uptake.