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ESI–MS Characterisation of Protein Adducts of Anticancer Ruthenium(II)‐Arene PTA (RAPTA) Complexes
Author(s) -
Casini Angela,
Mastrobuoni Guido,
Ang Wee Han,
Gabbiani Chiara,
Pieraccini Giuseppe,
Moneti Gloriano,
Dyson Paul J.,
Messori Luigi
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600258
Subject(s) - ruthenium , adduct , electrospray ionization , chemistry , cytochrome c , lysozyme , mass spectrometry , stereochemistry , combinatorial chemistry , biochemistry , organic chemistry , chromatography , apoptosis , catalysis
Electrospray ionization mass spectrometry allows a rapid characterisation of the adducts formed between three novel anticancer ruthenium(II)‐arene PTA compounds and horse heart cytochrome c or hen egg white lysozyme. Specific information on the nature of the protein‐bound metallic fragments and the extent of protein metallation was readily obtained.