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The Cytotoxicity of Saponins Correlates with Their Cellular Internalization
Author(s) -
Wang Yibing,
Zhang Yichun,
Yu Biao
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600235
Subject(s) - internalization , cytotoxicity , organelle , membrane , microbiology and biotechnology , cell , chemistry , computational biology , tumor cells , biology , biochemistry , in vitro , cancer research
Sneaking in unexpectedly : Saponins are a broad class of plant‐derived compounds that are commonly used as a tool to disrupt cell membranes. Some saponins such as that shown above, however, do not anchor themselves to the cell membrane, but are instead internalized. They localize specifically to acidic organelles such as lysosomes, and inhibit the growth of tumor cells.