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The Anionic Boron Cluster (B 12 H 11 SH) 2− as a Means To Trigger Release of Liposome Contents
Author(s) -
Gabel Detlef,
Awad Doaa,
Schaffran Tanja,
Radovan Diana,
Dărăban Daniel,
Damian Luminita,
Winterhalter Mathias,
Karlsson Göran,
Edwards Katarina
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600227
Subject(s) - liposome , limiting , chemistry , boron , drug carrier , drug , pharmacology , toxicity , combinatorial chemistry , medicine , biochemistry , organic chemistry , mechanical engineering , engineering
Triggered release . Liposomes are novel carriers for pharmaceutical agents and can be triggered to release their contents by the addition of B 12 H 11 SH, a compound in clinical use. As systemic toxicity is decreased relative to the free drug, liposomal drugs can therefore be administered in higher concentrations before dose‐limiting side effects are met. Thus, liposome‐encapsulated drugs may be of great value in the therapy of diseases.