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Structure‐Based Organic Synthesis of Drug Prototypes: A Personal Odyssey
Author(s) -
Hanessian Stephen
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600203
Subject(s) - natural (archaeology) , organic synthesis , conjunction (astronomy) , chemistry , drug discovery , computer science , combinatorial chemistry , biochemical engineering , nanotechnology , organic chemistry , engineering , materials science , biochemistry , biology , physics , paleontology , astronomy , catalysis
A “reorientation” of the concept of total synthesis of natural products emphasizes a biology‐inspired, chemistry‐driven approach without compromising the sanctity of basic research and the noble objectives of co‐worker training in an academic setting. Structure‐based organic synthesis provides a unique framework to capitalize on data gleaned from the bioactivity of natural products in conjunction with X‐ray crystallography, molecular modeling, and NMR spectroscopy for the design and synthesis of new drug prototypes.