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Granulatoside A, a Starfish Steroid Glycoside, Enhances PC12 Cell Neuritogenesis Induced by Nerve Growth Factor through an Activation of MAP Kinase
Author(s) -
Qi Jianhua,
Han Chunguang,
Sasayama Yumi,
Nakahara Hiroko,
Shibata Takahiro,
Uchida Koji,
Ojika Makoto
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600190
Subject(s) - starfish , nerve growth factor , chemistry , glycoside , kinase , phosphorylation , microbiology and biotechnology , biochemistry , receptor , biology , stereochemistry , ecology
Improving NGF: Granulatoside A was rediscovered from a different starfish and found to enhance the neuritogenic activity of nerve growth factor up to 40‐fold. The glycoside at the side chain seemed to be important for its activity. This effect is attributable to both enhancement and maintenance of the phosphorylation of MAP kinase ERK1/2.