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Topical Delivery of Silver Nanoparticles Promotes Wound Healing
Author(s) -
Tian Jun,
Wong Kenneth K. Y.,
Ho ChiMing,
Lok ChunNam,
Yu WingYiu,
Che ChiMing,
Chiu JenFu,
Tam Paul K. H.
Publication year - 2007
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600171
Subject(s) - wound healing , silver nanoparticle , inflammation , antimicrobial , nanoparticle , medicine , pharmacology , nanotechnology , chemistry , materials science , immunology , organic chemistry
Abstract Wound healing is a complex process and has been the subject of intense research for a long time. The recent emergence of nanotechnology has provided a new therapeutic modality in silver nanoparticles for use in burn wounds. Nonetheless, the beneficial effects of silver nanoparticles on wound healing remain unknown. We investigated the wound‐healing properties of silver nanoparticles in an animal model and found that rapid healing and improved cosmetic appearance occur in a dose‐dependent manner. Furthermore, through quantitative PCR, immunohistochemistry, and proteomic studies, we showed that silver nanoparticles exert positive effects through their antimicrobial properties, reduction in wound inflammation, and modulation of fibrogenic cytokines. These results have given insight into the actions of silver and have provided a novel therapeutic direction for wound treatment in clinical practice.