Synthesis and Biological Evaluation of a Multiantigenic Tn/TF‐Containing Glycopeptide Mimic of the Tumor‐Related MUC1 Glycoprotein | Zendy

Cremer GaëlleAnne | Zendy; Bureaud Nicole | Zendy; Piller Véronique | Zendy; Kunz Horst | Zendy; Piller Friedrich | Zendy; Delmas Agnès F. | Zendy

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Synthesis and Biological Evaluation of a Multiantigenic Tn/TF‐Containing Glycopeptide Mimic of the Tumor‐Related MUC1 Glycoprotein

Author(s) -

Cremer GaëlleAnne,

Bureaud Nicole,

Piller Véronique,

Kunz Horst,

Piller Friedrich,

Delmas Agnès F.

Publication year - 2006

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200600104

Subject(s) - glycopeptide , muc1 , epitope , glycoprotein , construct (python library) , mucin , native chemical ligation , computational biology , adjuvant , chemistry , immune system , biochemistry , biology , computer science , immunology , antigen , chemical synthesis , in vitro , programming language , antibiotics

The glycopeptide construct shown was synthesized using a convergent strategy based on oxime chemical ligation. It is composed of a universal T‐helper and three tumor‐related epitopes from the human mucin MUC1, an nonglycosylated repeat unit, and two units glycosylated with the Tn and TF epitopes, respectively. In association with a mild adjuvant suitable for human therapy, this construct elicited a strong specific immune response in mice, directed against natural tumor‐associated structures.

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