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Synthesis and Biological Evaluation of a Multiantigenic Tn/TF‐Containing Glycopeptide Mimic of the Tumor‐Related MUC1 Glycoprotein
Author(s) -
Cremer GaëlleAnne,
Bureaud Nicole,
Piller Véronique,
Kunz Horst,
Piller Friedrich,
Delmas Agnès F.
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600104
Subject(s) - glycopeptide , muc1 , epitope , glycoprotein , construct (python library) , mucin , native chemical ligation , computational biology , adjuvant , chemistry , immune system , biochemistry , biology , computer science , immunology , antigen , chemical synthesis , in vitro , programming language , antibiotics
The glycopeptide construct shown was synthesized using a convergent strategy based on oxime chemical ligation. It is composed of a universal T‐helper and three tumor‐related epitopes from the human mucin MUC1, an nonglycosylated repeat unit, and two units glycosylated with the Tn and TF epitopes, respectively. In association with a mild adjuvant suitable for human therapy, this construct elicited a strong specific immune response in mice, directed against natural tumor‐associated structures.