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The Synthesis and Testing of Arenearylpyrimidylmethanes as Antimalarial Agents
Author(s) -
Yepuri Nageshwar R.,
Haritakul Rachada,
Griffith Renate,
Leach Scott P.,
Keller Paul A.
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600062
Subject(s) - computer science , class (philosophy) , atropisomer , computational biology , convergent synthesis , chemistry , combinatorial chemistry , stereochemistry , artificial intelligence , biology
Do the two‐step : A new convergent synthesis of the arenearylpyrimidylmethane (AAPM) scaffold requires only two steps, and subsequent derivatisation yielded the potent lead 1 against a multidrug‐resistant malarial strain. The presence of atropisomerism with this class of compounds is also reported.