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Characterization of Solid Counterfeit Drug Samples by Desorption Electrospray Ionization and Direct‐analysis‐in‐real‐time Coupled to Time‐of‐flight Mass Spectrometry
Author(s) -
Fernández Facundo M.,
Cody Robert B.,
Green Michael D.,
Hampton Christina Y.,
McGready Rose,
Sengaloundeth Sivong,
White Nicholas J.,
Newton Paul N.
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600041
Subject(s) - dart ion source , counterfeit , desorption electrospray ionization , mass spectrometry , dart , ambient ionization , time of flight mass spectrometry , analytical chemistry (journal) , ionization , chemistry , sample preparation , electrospray ionization , chromatography , computer science , chemical ionization , electron ionization , ion , programming language , organic chemistry , political science , law
Vacuum is not the limit : direct analysis in real time (DART), a new MS ionization method, allows probing of pharmaceuticals under atmospheric pressure, thus bypassing lengthy sample preparation steps and enhancing throughput. DART allows rapid screening of solid drugs at almost constant temperature which decreases errors in mass measurement and improves the identification of potentially harmful unknowns. This is important for identifying counterfeit drugs (fake hologram shown).