Premium
A High‐Affinity Carbohydrate‐Containing Inhibitor of Matrix Metalloproteinases
Author(s) -
Calderone Vito,
Fragai Marco,
Luchinat Claudio,
Nativi Cristina,
Richichi Barbara,
Roelens Stefano
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600020
Subject(s) - matrix metalloproteinase , enzyme , chemistry , biochemistry , carbohydrate , matrix (chemical analysis) , computational biology , biology , chromatography
Matrix metalloproteinases (MMPs) are a class of Zn‐containing hydrolases that participate in a variety of biological processes, and aberrant activity of MMPs has been implicated in a number of diseases including cancer. A new glycoside‐containing inhibitor of MMPs, unprecedented among the inhibitors of this family of enzymes, is reported. This inhibitor is water soluble, and displays nanomolar affinity toward several MMPs.