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Permeability of Phospholipid Vesicles to the Tumor Antigen Epitope gp100 280–288
Author(s) -
Cavazza Antonella,
Marini Mario,
Spagnoli Giulio C.,
Adamina Michel,
Roda L. Giorgio
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600019
Subject(s) - epitope , vesicle , phospholipid , chemistry , antigen , peptide , permeability (electromagnetism) , biochemistry , biology , membrane , immunology
The permeability of phospholipid vesicles to a class I‐restricted epitope derived from the melanoma‐associated protein, gp100 280–288 , and its possible effects on epitope degradation by fibroblast‐expressed proteolytic enzymes were studied. The results indicate that the majority of the peptide may not be contained within the lipid vesicles when administered for vaccination.