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The Nuclear Receptor Superfamily and Drug Discovery
Author(s) -
Moore John T.,
Collins Jon L.,
Pearce Kenneth H.
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200600006
Subject(s) - nuclear receptor , drug discovery , glucocorticoid receptor , receptor , computational biology , ligand (biochemistry) , drug , drug development , chemistry , biology , pharmacology , bioinformatics , biochemistry , gene , transcription factor
Targeting the nuclear receptors : The ligand‐binding domain of the glucocorticoid receptor (ribbon) bound with the ligand, dexamethasone (space‐filling) is just one of the many pictures that are becoming clearer in the field of nuclear receptor (NR) research. Recent developments in drug discovery show great promise for the treatment of many NR‐related diseases.