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Modulators of the Kynurenine Pathway of Tryptophan Metabolism: Synthesis and Preliminary Biological Evaluation of ( S )‐4‐(Ethylsulfonyl)benzoylalanine, a Potent and Selective Kynurenine Aminotransferase II (KAT II) Inhibitor
Author(s) -
Pellicciari Roberto,
Rizzo Rosa C.,
Costantino Gabriele,
Marinozzi Maura,
Amori Laura,
Guidetti Paolo,
Wu HuiQiu,
Schwarcz Robert
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200500095
Subject(s) - kynurenine , kynurenic acid , kynurenine pathway , tryptophan metabolism , enzyme , metabolism , chemistry , biochemistry , tryptophan , indoleamine 2,3 dioxygenase , pharmacology , biology , amino acid
( S )‐4‐(Ethylsulfonyl)benzoylalanine is a potent and selective inhibitor of kynurenine aminotransferase II (KAT II) with no significant effect on KAT I or other enzymes of the kynurenine pathway. This compound is able to pronouncedly inhibit the formation of kynurenic acid (KYNA) in rat brain.