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T4 Phage Photoinactivation by Linear Furocoumarins and Angular Furoquinolinones
Author(s) -
Bettio Frazia,
Baccichetti Francarosa,
Simonato Morena,
Marzano Cristina,
Bordin Franco
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200500084
Subject(s) - furocoumarins , dna , bifunctional , chemistry , biology , microbiology and biotechnology , biochemistry , photochemistry , catalysis
TMP, FQ, and HFQ kill T4 phage under mild experimental conditions in its virion form, but not in its vegetative form. The process occurs through a two‐step irradiation procedure, characteristic of DNA bifunctional lesions. We hypothesize the induction of DNA–protein cross‐links in mature phages that can inhibit the infection process.