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Inhibitors of Mitotic Kinesins: Next‐Generation Antimitotics
Author(s) -
Sarli Vasiliki,
Giannis Athanassios
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200500045
Subject(s) - kinesin , mitosis , molecular motor , microbiology and biotechnology , microtubule , biology , chemistry
Turning the motors off : Mitotic kinesins are molecular motors that play a central role in cell division. Small molecules that block kinesin activity can lead to mitotic arrest, apparent in the formation of a monoaster within the cell (shown). Kinesin‐targeted molecules hold great potential as an alternative strategy in cancer chemotherapy.