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Click Chemistry on Azidoproline: High‐Affinity Dual Antagonist for HIV‐1 Envelope Glycoprotein gp120
Author(s) -
Gopi Hosahudya N.,
Tirupula Kalyan C.,
Baxter Sabine,
Ajith Sandya,
Chaiken Irwin M.
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200500037
Subject(s) - glycoprotein , ccr5 receptor antagonist , conjugate , human immunodeficiency virus (hiv) , envelope (radar) , receptor , dual (grammatical number) , chemistry , viral envelope , antagonist , dual role , computational biology , microbiology and biotechnology , virology , computer science , biochemistry , biology , combinatorial chemistry , philosophy , chemokine receptor , telecommunications , mathematics , mathematical analysis , radar , chemokine , linguistics
High affinity dual antagonist : The envelope glycoprotein gp120 of HIV‐1 mediates the first steps of viral entry into the host cell. An azidoproline‐based peptide conjugate 1 blocks the interaction of gp120 with both the CD4 cell‐surface receptor and 17b (an antibody surrogate of the CCR5 co‐receptor). It represents a potentially effective approach in preventing HIV infection.