Click Chemistry on Azidoproline: High‐Affinity Dual Antagonist for HIV‐1 Envelope Glycoprotein gp120 | Zendy

Gopi Hosahudya N. | Zendy; Tirupula Kalyan C. | Zendy; Baxter Sabine | Zendy; Ajith Sandya | Zendy; Chaiken Irwin M. | Zendy

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Click Chemistry on Azidoproline: High‐Affinity Dual Antagonist for HIV‐1 Envelope Glycoprotein gp120

Author(s) -

Gopi Hosahudya N.,

Tirupula Kalyan C.,

Baxter Sabine,

Ajith Sandya,

Chaiken Irwin M.

Publication year - 2006

Publication title -

chemmedchem

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.817

H-Index - 100

eISSN - 1860-7187

pISSN - 1860-7179

DOI - 10.1002/cmdc.200500037

Subject(s) - glycoprotein , ccr5 receptor antagonist , conjugate , human immunodeficiency virus (hiv) , envelope (radar) , receptor , dual (grammatical number) , chemistry , viral envelope , antagonist , dual role , computational biology , microbiology and biotechnology , virology , computer science , biochemistry , biology , combinatorial chemistry , philosophy , chemokine receptor , telecommunications , mathematics , mathematical analysis , radar , chemokine , linguistics

High affinity dual antagonist : The envelope glycoprotein gp120 of HIV‐1 mediates the first steps of viral entry into the host cell. An azidoproline‐based peptide conjugate 1 blocks the interaction of gp120 with both the CD4 cell‐surface receptor and 17b (an antibody surrogate of the CCR5 co‐receptor). It represents a potentially effective approach in preventing HIV infection.

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