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Aminothiazole Derivatives as Neuropeptide Y5 Receptor Ligands: Finding the Balance between Affinity and Physicochemical Properties
Author(s) -
Nettekoven Matthias,
Guba Wolfgang,
Neidhart Werner,
Mattei Patrizio,
Pflieger Philippe,
Plancher JeanMarc,
Taylor Sven
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200500022
Subject(s) - chemistry , linker , thiazole , membrane permeability , receptor , neuropeptide , solubility , combinatorial chemistry , neuropeptide y receptor , membrane , stereochemistry , biochemistry , organic chemistry , computer science , operating system
Potential appetite control: A straightforward parallel solution‐phase synthesis of novel thiazole derivatives with varying linker moieties gave access to a set of compounds 1 . Assessments of artificial membrane permeability and solubility show that some members of this compound class may be suitable antagonists for the neuropeptide Y5 receptor, which is involved in the stimulation of food intake.