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Structural Remodeling of Cocaine: Design and Synthesis of Trisubstituted Cyclopropanes as Selective Serotonin Reuptake Inhibitors
Author(s) -
Kozikowski Alan P.,
Zhao Lianyun,
Zhang Ao,
Wang Cheng Z.,
FlippenAnderson Judith,
Johnson Kenneth M.
Publication year - 2006
Publication title -
chemmedchem
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.817
H-Index - 100
eISSN - 1860-7187
pISSN - 1860-7179
DOI - 10.1002/cmdc.200500016
Subject(s) - sulfonium , cyclopropane , serotonin , chemistry , reuptake inhibitor , pharmacology , reuptake , serotonin transporter , stereochemistry , medicine , biochemistry , receptor , organic chemistry , ring (chemistry) , salt (chemistry)
Blocking transporters : A series of novel cyclopropane analogues 1 structurally related to cocaine were synthesized by using a sulfonium ylide based cyclopropanation reaction of benzylidenemalonate. As selective serotonin reuptake inhibitors (SSRIs) have proven effective against depression and other neurological disorders, these easily synthesized ligands are of potential therapeutic interest.