Open AccessCell locomotion: New research tests old ldeas on membrane and cytoskeletal flow
Author(s) -
Heath Julian P.,
Holifield Bruce F.
Publication year - 1991
Publication title -
cell motility and the cytoskeleton
Language(s) - English
Resource type - Journals
eISSN - 1097-0169
pISSN - 0886-1544
DOI - 10.1002/cm.970180402
Subject(s) - biology , cytoskeleton , microbiology and biotechnology , actin , cell membrane , crawling , cell , membrane protein , membrane , biophysics , anatomy , biochemistry
Recent studies on the mobility of membrane markers on crawling cells indicate that there is no long‐range centripetal flow of membrane proteins or lipids during cell locomotion. In this article we reflect on the history of ideas about membrane flow in cells, and we discuss how these new findings will shift the focus of research in cell locomotion away from the cell surface to the molecular interactions and dynamics of the actin cytoskeleton.