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P53 in RhoA regulation
Author(s) -
Barabutis Nektarios
Publication year - 2020
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21604
Subject(s) - rhoa , biology , small gtpase , gtpase , suppressor , disease , human disease , microbiology and biotechnology , cancer research , neuroscience , signal transduction , genetics , medicine , gene
Recent evidence suggest that dysregulation of the tumor suppressor P53, in combination with disharmonious activities of the small GTPase RhoA, may lead to irreversible progression of human disease. The purpose of the present study is to communicate the most recent information regarding the highly interrelated P53/RhoA network. Laborious investigations in the association between both components, may reveal new targets for opposing severe human disease, including the acute respiratory distress syndrome.