Premium
Emerging roles of the centrosome in neuronal development
Author(s) -
Meka Durga Praveen,
Scharrenberg Robin,
Calderon de Anda Froylan
Publication year - 2020
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21593
Subject(s) - centrosome , biology , microbiology and biotechnology , microtubule , cell polarity , centrosome cycle , cytokinesis , centriole , actin , neuroscience , cell division , cell , cell cycle , genetics
The role of the centrosome—a microtubule‐organizing center—in neuronal development has been under scrutiny and is controversial. The function and position of the centrosome have been shown to play an important role in selecting the position of axon outgrowth in cultured neurons and in situ. However, other studies have shown that axonal growth is independent of centrosomal functions. Recent discoveries define the centrosome as an F‐actin organizing organelle in various cell types; thus, giving a whole new perspective to the role of the centrosome in lymphocyte polarity, cell division, and neuronal development. These discoveries compel the need to revisit centrosomal functions by investigating the fundamental mechanisms that regulate centrosomal F‐actin remodeling during neuronal differentiation and polarization. In this review, we summarize the up‐to‐date knowledge regarding the function of the centrosome in neuronal differentiation. We put special emphasis on recent findings describing the centrosome as an F‐actin organizing center. Additionally, with the available data regarding centrosome, microtubules and F‐actin organization, we provide a model on how centrosomal F‐actin could be modulating neuronal differentiation and polarity.