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Orchestrating mitochondria in neurons: Cytoskeleton as the conductor
Author(s) -
CardanhoRamos Carlos,
FariaPereira Andreia,
Morais Vanessa Alexandra
Publication year - 2019
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21585
Subject(s) - biology , mitophagy , microbiology and biotechnology , cytoskeleton , crosstalk , mitochondrion , autophagy , cell , biochemistry , apoptosis , physics , optics
Mitochondria are crucial to support synaptic activity, particularly through ATP production and Ca 2+ homeostasis. This implies that mitochondria need to be well distributed throughout the different neuronal sub‐compartments. To achieve this, a tight and precise regulation of several neuronal cytoskeleton players is necessary to transport and dock mitochondria. As post‐mitotic cells, neurons are highly dependent on mitochondrial quality control mechanisms and several cytoskeleton proteins have been implicated in mitophagy. Therefore, all of these processes are orchestrated by the crosstalk between mitochondria and the neuronal cytoskeleton to form a coordinated and tuned symphony.