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Architecture, remodeling, and functions of the septin cytoskeleton
Author(s) -
Marquardt Joseph,
Chen Xi,
Bi Erfei
Publication year - 2019
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21475
Subject(s) - septin , biology , microbiology and biotechnology , cytoskeleton , budding yeast , cell cortex , cytokinesis , cell cycle , function (biology) , cell cycle protein , cell division , cell , yeast , computational biology , neuroscience , saccharomyces cerevisiae , genetics
The septin family of proteins has fascinated cell biologists for decades due to the elaborate architecture they adopt in different eukaryotic cells. Whether they exist as rings, collars, or gauzes in different cell types and at different times in the cell cycle illustrates a complex series of regulation in structure. While the organization of different septin structures at the cortex of different cell types during the cell cycle has been described to various degrees, the exact structure and regulation at the filament level are still largely unknown. Recent advances in fluorescent and electron microscopy, as well as work in septin biochemistry, have allowed new insights into the aspects of septin architecture, remodeling, and function in many cell types. This mini‐review highlights many of the recent findings with an emphasis on the budding yeast model.

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