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Emerging roles for motor proteins in progenitor cell behavior and neuronal migration during brain development
Author(s) -
Dantas Tiago J.,
Carabalona Aurelie,
Hu Daniel Jun Kit,
Vallee Richard B.
Publication year - 2016
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21293
Subject(s) - biology , neocortex , morphogenesis , neuroscience , motor protein , cell migration , microbiology and biotechnology , dynein , progenitor cell , myosin , cytoskeleton , microtubule , cell , stem cell , genetics , gene
Over the past two decades, substantial progress has been made in visualizing and understanding neuronal cell migration and morphogenesis during brain development. Distinct mechanisms have evolved to support migration of the various cell types that compose the developing neocortex. A specific subset of molecular motors, so far consisting of cytoplasmic dynein 1, Kif1a and myosin II, are responsible for cytoskeletal and nuclear transport in these cells. This review focuses on the emerging roles for each of these motor proteins in the migratory mechanisms of neocortical cell types. We discuss how migration can be cell cycle regulated and how coordination of motor activity is required to ensure migratory direction. © 2016 Wiley Periodicals, Inc.