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Cytoskeletal signaling in TGF β‐induced epithelial–mesenchymal transition
Author(s) -
Nalluri Sandeep M.,
O'Connor Joseph W.,
Gomez Esther W.
Publication year - 2015
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21263
Subject(s) - cytoskeleton , epithelial–mesenchymal transition , biology , microbiology and biotechnology , transforming growth factor , signal transduction , mesenchymal stem cell , cell migration , transforming growth factor beta , cell , metastasis , cancer , genetics
Epithelial–mesenchymal transition (EMT) is a physiological process that plays an important role in embryonic development and wound healing and is appropriated during pathological conditions including fibrosis and cancer metastasis. EMT can be initiated by a variety of factors, including transforming growth factor (TGF)‐β, and is characterized by loss of epithelial features including cell–cell contacts and apicobasal polarity and acquisition of a motile, mesenchymal phenotype. A key feature of EMT is reorganization of the cytoskeleton and recent studies have elucidated regulation mechanisms governing this process. This review describes changes in gene expression patterns of cytoskeletal associated proteins during TGFβ‐induced EMT. It further reports TGFβ‐induced intracellular signaling cascades that regulate cytoskeletal reorganization during EMT. Finally, it highlights how changes in cytoskeletal architecture during EMT can regulate gene expression, thus further promoting EMT progression. © 2015 Wiley Periodicals, Inc.