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Prognostic biomarkers for HNSCC using quantitative real‐time PCR and microarray analysis: β‐tubulin isotypes and the p53 interactome
Author(s) -
Lobert Sharon,
Graichen Mary E.,
Hamilton Robert D.,
Pitman Karen T.,
Garrett Michael R.,
Hicks Chindo,
Koganti Tejaswi
Publication year - 2014
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21195
Subject(s) - biology , interactome , tubulin , cancer , head and neck squamous cell carcinoma , cisplatin , cancer research , microtubule , head and neck cancer , chemotherapy , microbiology and biotechnology , genetics , gene
In 2014, more than 40,000 people in the United States will be diagnosed with head and neck squamous cell cancer (HNSCC) and nearly 8400 people will die of the disease ( www.cancer.org/acs/groups ). Little is known regarding molecular targets that might lead to better therapies and improved outcomes for these patients. The incorporation of taxanes into the standard cisplatin/5‐fluouracil initial chemotherapy for HNSCC has been associated with improved response rate and survival. Taxanes target the β‐subunit of the tubulin heterodimers, the major protein in microtubules, and halt cell division at G2/M phase. Both laboratory and clinical research suggest a link between β‐tubulin expression and cancer patient survival, indicating that patterns of expression for β‐tubulin isotypes along with activity of tumor suppressors such as p53 or micro‐RNAs could be useful prognostic biomarkers and could suggest therapeutic targets. © 2014 Wiley Periodicals, Inc.