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Remembrance of Hugh E. Huxley, a founder of our field
Author(s) -
Pollard Thomas D.,
Goldman Yale E.
Publication year - 2013
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21141
Subject(s) - biology , dynein , microtubule , protein filament , actin , myosin , fiber diffraction , kinesin , motor protein , contraction (grammar) , biophysics , microbiology and biotechnology , anatomy , physics , diffraction , optics , biochemistry , endocrinology , x ray crystallography
Hugh E. Huxley (1924–2013) carried out structural studies by X‐ray fiber diffraction and electron microscopy that established how muscle contracts. Huxley's sliding filament mechanism with an ATPase motor protein taking steps along an actin filament, established the paradigm not only for muscle contraction but also for other motile systems using actin and unconventional myosins, microtubules and dynein and microtubules and kinesin. © 2013 Wiley Periodicals, Inc.