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Actin cytoskeleton in cell polarity and asymmetric division during mouse oocyte maturation
Author(s) -
Yi Kexi,
Li Rong
Publication year - 2012
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21048
Subject(s) - biology , polar body , cell polarity , microbiology and biotechnology , oocyte , cytoskeleton , polarity (international relations) , actin , meiosis , actin cytoskeleton , asymmetric cell division , cell division , cell , genetics , embryo , gene
Mammalian oocyte maturation involves two successive rounds of extremely asymmetric cell divisions (known as polar body extrusion) to generate a functional haploid egg. Successful polar body extrusion relies on establishment of an asymmetric spindle position and cortical polarity. Decades of studies using mouse oocytes as a model have revealed critical roles for a dynamic actin cytoskeleton in this process. Here, we review the contribution of actin to the critical events during oocyte meiotic cell divisions with an emphasis on recent advances in understanding the underlying molecular and physical mechanisms. © 2012 Wiley Periodicals, Inc