Premium
Polar opposites: Fine‐tuning cytokinesis through SIN asymmetry
Author(s) -
Johnson Alyssa E.,
McCollum Dannel,
Gould Kathleen L.
Publication year - 2012
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21044
Subject(s) - cytokinesis , biology , anaphase , microbiology and biotechnology , mitosis , mitotic exit , cell division , schizosaccharomyces pombe , septin , spindle apparatus , schizosaccharomyces , asymmetric cell division , asymmetry , genetics , cell , cell cycle , yeast , physics , saccharomyces cerevisiae , quantum mechanics
Mitotic exit and cell division must be spatially and temporally integrated to facilitate equal division of genetic material between daughter cells. In the fission yeast, Schizosaccharomyces pombe , a spindle pole body (SPB) localized signaling cascade termed the septation initiation network (SIN) couples mitotic exit with cytokinesis. The SIN is controlled at many levels to ensure that cytokinesis is executed once per cell cycle and only after cells segregate their DNA. An interesting facet of the SIN is that its activity is asymmetric on the two SPBs during anaphase; however, how and why the SIN is asymmetric has remained elusive. Many key factors controlling SIN asymmetry have now been identified, shedding light on the significance of SIN asymmetry in regulating cytokinesis. In this review, we highlight recent advances in our understanding of SIN regulation, with an emphasis on how SIN asymmetry is achieved and how this aspect of SIN regulation fine‐tunes cytokinesis. © 2012 Wiley Periodicals, Inc