Premium
The role of small GTPases in neuronal morphogenesis and polarity
Author(s) -
GonzalezBillault Christian,
MuñozLlancao Pablo,
Henriquez Daniel R.,
Wojnacki José,
Conde Cecilia,
Caceres Alfredo
Publication year - 2012
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21034
Subject(s) - biology , rhoa , cdc42 , microbiology and biotechnology , cytoskeleton , microtubule , gtpase , morphogenesis , polarity (international relations) , cell polarity , actin cytoskeleton , neuroscience , actin , rac1 , cell , genetics , signal transduction , gene
The highly dynamic remodeling and cross talk of the microtubule and actin cytoskeleton support neuronal morphogenesis. Small RhoGTPases family members have emerged as crucial regulators of cytoskeletal dynamics. In this review we will comprehensively analyze findings that support the participation of RhoA, Rac, Cdc42, and TC10 in different neuronal morphogenetic events ranging from migration to synaptic plasticity. We will specifically address the contribution of these GTPases to support neuronal polarity and axonal elongation. © 2012 Wiley Periodicals, Inc