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The chemical complexity of cellular microtubules: Tubulin post‐translational modification enzymes and their roles in tuning microtubule functions
Author(s) -
Garnham Christopher P.,
RollMecak Antonina
Publication year - 2012
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.21027
Subject(s) - microtubule , biology , tubulin , microbiology and biotechnology , posttranslational modification , function (biology) , enzyme , molecular motor , computational biology , biochemistry
Cellular microtubules are marked by abundant and evolutionarily conserved post‐translational modifications that have the potential to tune their functions. This review focuses on the astonishing chemical complexity introduced in the tubulin heterodimer at the post‐translational level and summarizes the recent advances in identifying the enzymes responsible for these modifications and deciphering the consequences of tubulin's chemical diversity on the function of molecular motors and microtubule associated proteins. Published 2012 Wiley Periodicals, Inc.