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Regulation of microtubule organization and functions by septin GTPases
Author(s) -
Spiliotis Elias T.
Publication year - 2010
Publication title -
cytoskeleton
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.95
H-Index - 86
eISSN - 1949-3592
pISSN - 1949-3584
DOI - 10.1002/cm.20448
Subject(s) - septin , biology , microtubule , gtpase , microbiology and biotechnology , microtubule associated protein , motor protein , function (biology) , cytoskeleton , cytokinesis , molecular motor , cell division , genetics , cell
Abstract Septins comprise an evolutionarily conserved family of oligomeric GTPases that regulate the intracellular localization of proteins by functioning as protein scaffolds and diffusion barriers. Recent studies reveal that septins associate with microtubules, microtubule‐associated proteins (MAPs), and microtubule motors. Here, I review these findings and consider how septins may spatially regulate the interaction of microtubules with MAPs and motor proteins. Thus, septins may constitute a novel regulatory module of microtubule organization and function with important implications in the understanding and treatment of cancer and neurodegeneration. © 2010 Wiley‐Liss, Inc.