Open AccessFunction of dynein in budding yeast: Mitotic spindle positioning in a polarized cell
Author(s) -
Moore Jeffrey K.,
StuchellBrereton Melissa D.,
Cooper John A.
Publication year - 2009
Publication title -
cell motility and the cytoskeleton
Language(s) - English
Resource type - Journals
eISSN - 1097-0169
pISSN - 0886-1544
DOI - 10.1002/cm.20364
Subject(s) - dynein , biology , microbiology and biotechnology , microtubule , astral microtubules , spindle pole body , mitosis , dynactin , cytoskeleton , saccharomyces cerevisiae , cell division , spindle apparatus , yeast , cell , genetics
Cytoplasmic dynein is a microtubule motor that powers minus‐end‐directed motility in a variety of biological settings. The budding yeast, Saccharomyces cerevisiae , has been a useful system for the study of dynein, due to its molecular genetics and cell biology capabilities, coupled with the conservation of dynein‐pathway proteins. In this review we discuss how budding yeast use dynein to manipulate the position of the mitotic spindle and the nucleus during cell division, using cytoplasmic microtubules, and we describe our current understanding of the genes required for dynein function. Cell Motil. Cytoskeleton 2009. © 2009 Wiley‐Liss, Inc.