Open AccessA case report of simultaneous thrombosis of two coronary artery stents in association with clopidogrel resistance
Author(s) -
Lee Jin Sun,
Dunn Steven P.,
Marshall Helen M.,
Cohen Mauricio G.,
Smyth Susan S.
Publication year - 2007
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.9
Subject(s) - medicine , clopidogrel , conventional pci , cardiology , thrombosis , antiplatelet drug , incidence (geometry) , platelet , artery , stent , aspirin , myocardial infarction , optics , physics
Despite aggressive antiplatelet therapy in the setting of PCI, the incidence of acute stent thrombosis remains approximately 0.5–2%. We report a patient with simultaneous thrombosis of two drug‐eluting coronary artery stents, suggesting a systemic thrombotic state. Evaluation by optical platelet aggregometry revealed clopidogrel resistance, which was overcome at a higher drug dose. We aim to highlight the potential utility of platelet function analysis to guide therapy for patients in whom inadequate antiplatelet therapy may have catastrophic clinical outcomes. Copyright © 2007 Wiley Periodicals, Inc.