Open AccessAldosterone blockade in post‐acute myocardial infarction heart failure
Author(s) -
Pitt Bertram,
Ferrari Roberto,
Gheorghiade Mihai,
van Veldhuisen Dirk J.,
Krum Henry,
McMurray John,
LopezSendon Jose
Publication year - 2006
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960291004
Subject(s) - medicine , aldosterone , blockade , myocardial infarction , heart failure , cardiology , intensive care medicine , receptor
Development of heart failure (HF) or left ventricular systolic dysfunction (LVSD) significantly increases mortality post acute myocardial infarction (AMI). Aldosterone contributes to the development and progression of HF post AMI, and major guidelines now recommend aldosterone blockade in this setting. However, lack of practical experience with aldosterone blockade may make clinicians hesitant to use these therapies. This review is based on a consensus cardiology conference that occurred in May 2005 (New York City) concerning these topics. Potential barriers to the use of aldosterone blockade are discussed and an algorithm for appropriate in‐hospital pharmacologic management of AMI with LVSD and/or HF is presented.