Open AccessDepression and thyroid axis function in coronary artery disease: Impact of cardiac impairment and gender
Author(s) -
Bunevicius Robertas,
Varoneckas Giedrius,
Prange Arthur J.,
Hinderliter Alan L.,
Gintauskiene Vilte,
Girdler Susan S.
Publication year - 2006
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960290409
Subject(s) - medicine , cardiology , coronary artery disease , depression (economics) , disease , cardiac function curve , thyroid function , thyroid , heart failure , economics , macroeconomics
Background : Increased rates of depression are reported in coronary artery disease (CAD). In heart disease, depression increases disability, reduces quality of life, and increases mortality. Hypothesis : The study was undertaken to examine the relationship between depression and thyroid axis function in patients with CAD. Methods : In all, 73 patients with CAD, consecutively admitted to a cardiac rehabilitation hospital, were assessed for depression using the Hospital Anxiety and Depression scale (HADS). Blood was drawnfor assessment of thyroid axis hormones and the N‐amino terminal fragment of the pro‐B‐type natriuretic peptide (NT‐pro BNP). Results : The patients with CAD with depressive symptoms had a higher prevalence of cardiac failure (p = 0.04), higher NT‐pro BNP concentrations (p = 0.02), and lower free tri‐iodothyronine (T3) concentrations (p = 0.04) than patients with CAD but without depressive symptoms. They also showed a strong trend (p = 0.058) toward a higher incidence of the low T3 syndrome. Higher NT‐pro BNP concentrations were related to lowertotal T3 concentrations (r = ‐0.294, p = 0.011) and to higher reverse T3 concentrations (r = 0.353, p = 0.002). In men, higher scores of depression were related to lower total T3 concentration (r = ‐0.289, p = 0.034) and to higher NT‐pro BNP concentration (r = 0.380, p = 0.005). Conclusion : These findings suggest that symptoms of depression in patients with CAD are associated with changes in thyroid axis function and with cardiac impairment, especially in men.