Open AccessAssociation of genetic polymorphisms in the fibrinogen and platelet glycoprotein genes with unstable angina in Chinese patients
Author(s) -
Yongbin Ni,
Dayi Hu,
Hong Yu,
Cuilan Li,
Wenling Liu,
Hongyu Wang,
Lei Li
Publication year - 2004
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960270807
Subject(s) - medicine , odds ratio , fibrinogen , genotype , allele , gastroenterology , unstable angina , platelet membrane glycoprotein , coronary artery disease , restriction fragment length polymorphism , allele frequency , genetics , platelet , gene , biology , coronary heart disease
Background : Inherited predisposition has been associated with coronary artery disease (CAD) in the white population. Hypothesis : The objective of this study was to investigate the association between the risk of unstable angina (UA) and genetic factors believed to be associated with an increased tendency toward thrombosis (the variable number of tandem repeats [VNTR] polymorphism of the platelet glycoprotein [GP] Iba gene, P1 A1/A2 of the platelet GP IIIa gene, 448G/A of the Bβ fibrinogen gene and Thr312 A1a of the Act fibrinogen gene) in Chinese patients with UA. Methods : We performed a case/control study evaluating 69 Chinese patients (43 men, 26 women) with UA and 69 control subjects without CAD, individually matched for age and gender. The restriction fragment length polymorphism (RFLP) method was used to determine the genetic polymorphisms. Results : The frequencies of GP Ibα C/B genotype and Bβ fibrinogen 448 A allele were higher in patients with UA (46.4 vs. 30.4%, odds ratio [OR] 1.977, 95% confidence interval [CI] 0.98‐3.97, p = 0.054, and 49.3 vs. 20.3%, OR 3.816, 95%CI 1.797‐8.103, p = 0.000, respectively). Only four subjects (two cases, two controls) with GP IIIa Pl A2 allele were found, and there was no association between Act fibrinogen Thr312Ala polymorphism and UA. Conclusions : Chinese patients with UA had increased frequencies of GP Iba C/B genotype and Bβ fibrinogen 448A allele. These data suggest that some genetic factors may influence the development of UA.