Open AccessRelation of circulating interleukin‐6 to left ventricular remodeling in patients with reperfused anterior myocardial infarction
Author(s) -
Ohtsuka Tomoaki,
Hamada Mareomi,
Inoue Katsuji,
Ohshima Kiyotaka,
Suzuki Jun,
Matsunaka Tsuyoshi,
Ogimoto Akiyoshi,
Hara Yuji,
Shigematsu Yuji,
Higaki Jitsuo
Publication year - 2004
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960270712
Subject(s) - medicine , ventricular remodeling , ejection fraction , cardiology , myocardial infarction , proinflammatory cytokine , heart failure , inflammation
Abstract Background: During the remodeling process after myocardial infarction (MI), the expression of proinflammatory cytokines is enhanced in the myocardium. However, only a few clinical studies have been conducted on cytokine involvement in left ventricular (LV) remodeling after MI. Hypothesis: Circulating proinflammatory cytokines may be involved in LV remodeling in patients with reperfused MI. Methods: We studied 25 patients with acute anterior MI who had undergone coronary reperfusion therapy, and 10 normal control subjects with no cardiac disease. In all patients, LV ejection fraction, end‐diastolic volume index (EDVI), and end‐systolic volume index (ESVI) were determined using left ventriculography at the acute phase and 6 months after onset. The ΔEDVI and ΔESVI were calculated as the value of LV volume reduction, suggesting LV reverse remodeling. Serum levels of interleukin (IL)‐6 and tumor necrosis factor (TNF)‐alpha were measured using enzyme‐linked immunosorbent assay. Results: Serum levels of IL‐6 and TNF‐alpha at the acute phase were significantly higher in patients with MI than in control subjects (both p < 0.05). The IL‐6 levels correlated well negatively with ΔEDVI (r = 0.779, p = 0.039), whereas no correlation was found for TNF‐alpha. According to multivariate analysis, IL‐6 at the acute phase was a significant independent predictor for LV remodeling after reperfused MI (p = 0.007). Conclusions: Circulating IL‐6 levels correlated closely with LV geometric changes during the remodeling process in patients with reperfused MI. Our study addresses the usefulness of another marker for LV remodeling after MI.