Open AccessBeta 1 ‐adrenergic receptor gene polymorphisms and response to Beta 1 ‐adrenergic receptor blockade in patients with essential hypertension
Author(s) -
Karlsson J.,
Lind L.,
Hallberg P.,
Michaëlsson K.,
Kurland L.,
Kahan T.,
Malmqvist K.,
Öhman K. P.,
Nyström F.,
Melhus H.
Publication year - 2004
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960270610
Subject(s) - atenolol , medicine , blood pressure , endocrinology , irbesartan , muscle hypertrophy , receptor , adrenergic receptor , heart rate , essential hypertension , angiotensin ii , left ventricular hypertrophy , receptor antagonist , heart failure , antagonist
Abstract Background: Studies suggest that the Ser49Gly and Arg389Gly polymorphisms in the β 1 ‐adrenergic receptor might be of functional importance for the cardiovascular system. Both have been associated with altered receptor activity in vitro, and with hypertension and cardiac failure in vivo. Hypothesis: The aim of this study was to test whether these polymorphisms were associated with the change in heart rate or blood pressure in patients with essential hypertension and left ventricular (LV) hypertrophy treated with the β 1 ‐adrenergic receptor blocker atenolol. Methods: Blood pressure and heart rate were measured in 101 hypertensive patients with echocardiographically verified LV hypertrophy, randomized in a double‐blind study to treatment with either the β 1 ‐adrenergic receptor blocker atenolol or the angiotensin II type I receptor antagonist irbesartan. Changes in blood pressure and heart rate were evaluated after 12 weeks. Beta 1 ‐adrenergic receptor genotyping was performed using polymerase chain reaction and restriction fragment length polymorphism. Results: We found no significant associations between the changes in the measured variables and either of the two polymorphisms. However, carriers of the 49Gly allele showed a tendency toward a greater reduction in heart rate compared with patients with the Ser/Ser49 genotype (p = 0.06). Conclusions: The Ser49Gly and Arg389Gly β 1 ‐adrenergic receptor polymorphisms do not seem to exert a major effect on the changes in heart rate and blood pressure during 12 weeks of treatment with atenolol in patients with essential hypertension and LV hypertrophy.