Open AccessImpact of left ventricular ejection fraction on endothelial function in patients with coronary artery disease
Author(s) -
Bae JangHo,
Bassenge Eberhard,
Kim MooHyun,
Park KiRack,
Kim KiYoung,
Synn YiChul,
Schwemmer Michael
Publication year - 2004
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960270606
Subject(s) - medicine , ejection fraction , cardiology , coronary artery disease , ventricular function , heart failure
Abstract Background: Endothelial dysfunction is present in patients with coronary artery disease (CAD) or with congestive heart failure. Hypothesis: This study was performed to evaluate the impact of systolic heart function on endothelial function in patients with CAD. Methods: The study population consisted of 283 consecutive patients (mean age 59 years, 176 men) undergoing coronary angiography. Endothelial function was assessed by measuring flow‐mediated vasodilation (FM.D) of the brachial artery. Results: Patients (n = 236) with an ejection fraction (EF) ≥ 55% on routine echocardiogram were younger (mean age 58 vs. 62 years), showed a lower prevalence of diabetes (15 vs. 38%) and myocardial infarction (13 vs. 66%), and showed a higher FM.D (4.8 ± 2.4 vs. 4.0 ± 2.0%, p < 0.05) than patients (n = 47) with an EF < 55%. The correlation coefficient between FM.D/endothelial function and EF/systolic heart function was 0.149 (p < 0.02) in the overall study population. Multivariate analysis showed that of age, gender, frequency of diabetes mellitus, myocardial infarction, and CAD extent, EF was the only significant independent parameter correlating with FM.D in patients with CAD. Conclusions: Compared with the other tested risk factors, EF surprisingly was the only significant independent parameter correlating with endothelial function in patients with CAD. Our results support the view that endothelial function is an independent prognostic factor in patients with CAD.