Open AccessComparison of hemostatic activation created by right‐ and left‐heart radiofrequency catheter ablation
Author(s) -
Charng MinJi,
Lin YennJiang,
Chiu TingYu,
Cheng ChienMin,
Ding Philip YuAn
Publication year - 2004
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960270210
Subject(s) - medicine , ablation , platelet activation , catheter ablation , radiofrequency ablation , cardiology , platelet , hemostasis , right heart , surgery , anesthesia
Background : Thromboembolic complications commonly occur in radiofrequency (RF) ablation procedures (0.6‐1.3% of cases). Comparison of hemostatic activation between left and right RF ablation is limited. Hypothesis : The purpose of this study was to evaluate platelet and hemostatic activation before, immediately after, and 48 h following left and right myocardial RF ablation procedures. Methods : The subjects were two groups of patients who underwent right‐heart (24 patients) and left‐heart (20 patients) RF ablation. Blood samples taken before, immediately after, and 48 h after the procedure were tested for changes in platelet and hemostatic activation. Results : No indication of clinically symptomatic thrombo‐embolism and no major differences in baseline characteristics and procedure were apparent in either group, except for a higher temperature mode setting (p < 0.001) in the left‐heart group. The hemostatic evaluation levels increased significantly by the end of the procedure in both groups and the platelet activation level remained elevated for 48 h after the procedure. The platelet activation level increased insignificantly at the end and 48 h after the procedure. Of the other changes in levels of platelet and hemostatic activation, only an increase in one of the hemostatic levels in the right‐heart group at 48 h after procedure was significant (p = 0.01). Conclusions : Our findings suggest that similar hemostatic activation occurred during and immediately after RF ablation in both groups. Sustained elevation of the hemostatic marker after the ablation procedure in the right‐heart group was observed as of significant therapeutic and prognostic implications.