Open AccessFibrin D‐dimer: A marker of psychosocial distress and its implications for research in stress‐related coronary artery disease
Author(s) -
Von Känel Roland,
Dimsdale Joel E.
Publication year - 2003
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960260403
Subject(s) - medicine , psychosocial , distress , d dimer , prospective cohort study , coronary artery disease , cardiology , risk factor , fibrin , clinical psychology , psychiatry , immunology
Psychosocial factors might mediate their adverse impact on coronary arteries by eliciting a hypercoagulable state via changes in sympathetic nervous system activity. A recent meta‐analysis of prospective studies reported an association of the hypercoagulability marker D‐dimer with an increased risk for coronary events. This review provides evidence that an elevated plasma D‐dimer level is a suitable marker for acute and chronic psychosocial distress. Prospective studies need to show whether stress‐related changes in D‐dimer may help explain the increased coronary risk with psychosocial distress.