Open AccessLipoprotein(a) was an independent predictor for major coronary events in treated hypertensive men
Author(s) -
Agewall Stefan,
Fagerberg Björn
Publication year - 2002
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960250609
Subject(s) - medicine , myocardial infarction , cardiology , angina , lipoprotein , lipoprotein(a) , diabetes mellitus , risk factor , coronary atherosclerosis , proportional hazards model , coronary heart disease , prospective cohort study , cholesterol , endocrinology
Abstract Background and Hypothesis : Lipoprotein(a) may play a part in the development of coronary heart disease. The purpose of this prospective study was to evaluate lipoprotein(a) as a predictor of major coronary events (fatal and nonfatal myocardial infarction and sudden death). Methods : This was a prospective study of 118 men, aged 56 to 77 years, with treated hypertension and at least one additional cardiovascular risk factor (hypercholesterolemia, diabetes mellitus, or smoking) were included in the study. Lipoprotein(a) was measured at entry and major coronary events were followed during follow‐up. Results : The mean observation time was 3.0 years. Fourteen patients had a major coronary event during the follow‐up period. Subjects with coronary heart disease (previous myocardial infarction, angina pectoris, or major electrocardiographic changes) at entry (n = 27) had significantly higher lipoprotein(a) levels than subjects without (n = 91) known coronary heart disease (p < 0.05). Lipoprotein(a) was a significant predictor for major coronary events (p = 0.033). Furthermore, when coronary disease at entry was included into the Cox regression analysis, lipoprotein(a) was an independent predictorfor major coronary events (p = 0.044). Conclusions : Among treated hypertensive men, lipoprotein(a) was an independent predictor of major coronary events.