Open AccessVascular cell adhesion molecule‐1 and intercellular adhesion molecule‐1 serum level in patients with chest pain and normal coronary arteries (syndrome X)
Author(s) -
Tousoulis Dimitris,
Daves Graham J.,
Asimakopoulos George,
Homaei Homeyra,
Zouridakis Emmanouil,
Ahmed Nabeel,
Kaski Juan Carlos
Publication year - 2001
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960240409
Subject(s) - medicine , chest pain , coronary artery disease , coronary arteries , pathogenesis , cardiology , cell adhesion molecule , endothelium , cardiac syndrome x , inflammation , intercellular adhesion molecule , acute coronary syndrome , angina , unstable angina , artery , adhesion , cell adhesion , myocardial infarction , immunology , chemistry , organic chemistry
Background : Plasma levels of soluble vascular cell adhesion molecule‐1 (VCAM‐1) and intercellular adhesion molecule‐1 (IC AM‐1) mediators of leukocyte adhesion to vascular endothelium may implicate in the pathogenesis of the syndrome of chest pain with normal coronary arteries. Hypothesis : We attempted to determine whether markers of endothelial activation are raised in patients with chest pain and normal coronary arteries. Methods : We measured plasma VCAM‐1, ICAM‐1 (ng/ml) in 36 patients (34 men, 2 women, aged 62 ± 9 years) with stable angina, coronary artery disease (CAD), and a positive response to exercise test; in 21 patients (6 men, 15 women, aged 56 ± 9 years) with chest pain and normal coronary arteriograms (syndrome X); and in 11 healthy control subjects (8 men, 3 women, aged 49 ± 14 years). Results : Plasma ICAM‐1 levels were significantly higher both in patients with CAD (mean ± standard error of the mean) (328 ± 26, p<0.05), and in syndrome X (362 ± 22, p<0.01) than in controls (225 ± 29). VCAM‐1 levels were also higher in syndrome X (656 ± 42 ng/ml) and in patients with CAD (626 ± 42 ng/ml) than in controls (551 ± 60, p=0.09). Conclusions : ICAM‐1 and VCAM‐1 levels are increased both in patients with CAD and with syndrome X compared with control individuals. These findings may suggest the presence of chronic inflammation with involvement of the endothelium in patients with anginal chest pain and normal coronary angiograms.