Open AccessCan cocaine abuse exacerbate the cardiac toxicity of human immunodeficiency virus?
Author(s) -
Soodini Geetha,
Morgan James P.
Publication year - 2001
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960240302
Subject(s) - medicine , cardiac toxicity , toxicity , human immunodeficiency virus (hiv) , cardiac dysfunction , cocaine abuse , concomitant , immunology , pharmacology , virology , heart failure , psychiatry
Abstract Both cocaine use and human immunodeficiency virus (HIV) infection alone have been associated with an increased incidence of cardiac dysfunction. Concomitant exposure to cocaine and HIV infection may exacerbate the cardiac toxicity of either agent alone, a hypothesis that is examined in this review article. A possible unifying hypothesis based on enhancement of adrenergic stimulation is proposed.