Open AccessTherapeutic myocardial angiogenesis using percutaneous intrapericardial drug delivery
Author(s) -
Laham Roger J.,
Simons Michael,
Hung Daw
Publication year - 1999
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960221305
Subject(s) - medicine , angiogenesis , percutaneous , drug delivery , drug , pericardial window , bolus (digestion) , pericardium , cardiology , pharmacology , surgery , chemistry , organic chemistry
In this manuscript, we describe the potential role of the pericardial space as a drug delivery reservoir to administer angiogenic agents to the heart resulting in functionally significant angiogenesis with single bolus basic fibroblast growth factor (bFGF) delivery. We also describe a percutaneous subxyphoid pericardial access technique that is safe, rapid, and reliable.