Discontinuous conduction in the heart

Preface Section I: Normal Cardiac Conduction: Introduction 1. Discontinuous Cardiac Conduction: Its Origin in Cellular Connectivity With Long-Term Adaptive Changes That Cause Arrhythmias 2. Gap Junction Channels and Cardiac Conduction 3. Nonjunctional Channels of Cardiac Cells and Metabolic Oscillations as Contributors to Discontinuous Conduction Section II: Discontinuous Conduction and Arrhythmias: Introduction: 4. Gap Junction Structure, Conduction, and Arrhythmogenesis: Directions for Future Research 5. Role of Discontinuous Electrical Propagation in Clinical Atrial Arrhythmias: Current Evidence and Future Directions 6. Role of Discontinuous Conduction/Nonuniform Anisotropy in Clinical Arrhythmias Section III: Gating and Modulation of Gap Junctions: Introduction: 7. Structure of Cardiac Gap Junction Membrane Channels: Progress Toward a Higher-Resolution Model 8. Major Cell Biological Issues and Strategies in Discontinuous Conduction 9. Molecular Analysis of the pH Regulation of the Cardiac Gap Junction Protein Connexin43 10. Triggered Propagated Contractions and Arrhythmias Caused by Acute Damage to Cardiac Muscle 11. Microscopic Conduction in Cell Cultures Assessed by High-Resolution Optical Mapping and Computer Simulation Section IV: Waves and Arrhythmias: Introduction: 12. Scale of Geometric Structures Responsible for Discontinuous Propagation in Myocardial Tissue 13. Wave-Front Curvature Leads to Slow Conduction and Block in Two-Dimensional Cardiac Muscle 14. Antiarrhythmic and Proarrhythmic Mechanisms in Cardiac Tissue: Linking Spiral Waves, Reentrant Arrhythmias, and Electrocardiographic Patterns Section V: Junctional Channels and Molecular Genetics: Introduction: 15. Molecular and Biochemical Regulation of Connexins: Potential Targets for Modulation of Cardiac Intercellular Communication 16. Can We Learn About Conduction by Use of Genetic Approaches? Section VI: Discontinuous Conduction in Myocardial Ischemia: Introduction: 17. Characteristics and Causes of Conduction Changes Associated With 1a and 1b Arrhythmias in Acute Ischemia 18. Discontinuous Conduction in the Epicardial Border Zone of Infarcted Hearts and Its Role in Anisotropic Reentry 19. Is There a Pharmacology for Discontinuous Conduction? Section VII: Contemporary Model Studies of Discontinuous Conduction: Introduction: 20. Discontinous Conduction in the AV Junctional Area 21. Experimental Simulations of Variations in Junctional Conductance 22. Membrane Factors and Gap Junction Factors as Determinants of Ventricular Conduction and Reentry Perspectives and Future Directions: Arrhythmias and Discontinuous Conduction Index