Open AccessSimultaneous manifestation of acute myocardial infarction and nephrotic syndrome
Author(s) -
Meyer Thomas,
Schulze Friederike,
Kreuzer Heinrich,
Grone HermannJosef
Publication year - 1998
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960210713
Subject(s) - medicine , nephrotic syndrome , myocardial infarction , cardiology , thrombosis , acute coronary syndrome , edema , proteinuria , pathology , kidney
Abstract This report describes the simultaneous manifestation of ischemic heart disease and nephrotic syndrome in a 37‐year‐old woman presenting with acute anterior myocardial infarction. Symptoms of nephrotic syndrome, such as facial and peripheral edema accompanied by proteinuria and hyperlipidemia, and onset of severe retrosternal pain developed within 24 h. Coronary angiography revealed a complete thrombotic occlusion of the proximal portion of the left anterior descending artery with no evidence of arteriosclerotic lesions. Histologic examination of renal biopsy, including electron microscopy, revealed evidence of minimal change glomerulonephritis. Ultrastructural studies demonstrated widespread effacement of epithelial foot processes. Elevated levels of circulating fibrinogen appeared to be an important factor for the hypercoagulable state in this patient, suggesting a causative relationship between coronary thrombosis and nephrotic syndrome.