Open AccessVasospastic angina induced by nonsteroidal anti‐inflammatory drugs
Author(s) -
Mori Etsuo,
Ikeda Hisao,
Ueno Takafumi,
Kai Hisashi,
Haramaki Nobuya,
Hashing Tatsuya,
Ichiki Kazuya,
Katoh Atsushi,
Eguchi Hiroyuki,
Ueyama Takahisa,
Imaizumi Tsutomu
Publication year - 1997
Publication title -
clinical cardiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.263
H-Index - 72
eISSN - 1932-8737
pISSN - 0160-9289
DOI - 10.1002/clc.4960200713
Subject(s) - medicine , ergonovine , angina , chest pain , anesthesia , cardiology , kounis syndrome , coronary vasospasm , anaphylaxis , myocardial infarction , allergy , immunology , acute coronary syndrome
Abstract We report two cases of vasospastic angina associated with anaphylactic reaction caused by nonsteroidal antiinflammatory drugs (NSAIDs). Both patients exhibited anaphylactic manifestations, such as general rash and urticaria, along with angina pectoris with electrocardiographic ST‐segment elevations after suppository administration of diclofenac sodium or indomethacin, the most commonly used NSAIDs. Although these patients had normal coronary arteriograms, intracoronary administration of ergonovine or acetylcholine provoked diffuse coronary artery spasms accompanied by chest pain and ischemic ST‐segment changes. It is therefore suggested that an allergic mechanism may be involved as a causative factor of the coronary artery spasm induced by NSAIDs.